Molecular Mechanisms of Tumor Angiogenesis
نویسندگان
چکیده
منابع مشابه
Molecular Mechanisms of Tumor Angiogenesis
It is well established that progression from a pre-malignant to malignant invasive tumor phenotype is dependent on angiogenesis1-7. As such, a hallmark of all solid cancers is their ability to induce the formation of their own blood supply thereby sustaining their growth and is characterized by increases in endothelial cell (EC) proliferation and blood vessel heterogeneity8-10. The ‘angiogenic ...
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Molecular imaging has recently been defined by the Society of Nuclear Medicine as ‘the visualization, characterization, and measurement of biological processes at the molecular and cellular levels in humans and other living systems’ (Mankoff 2007). It usually exploits specific labeled molecular probes, as well as intrinsic tissue characteristics as the source of image contrast, and uses a numbe...
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Often those diseases most evasive to therapeutic intervention usurp the human body's own cellular machinery or deregulate normal physiological processes for propagation. Tumor-induced angiogenesis is a pathological condition that results from aberrant deployment of normal angiogenesis, an essential process in which the vascular tree is remodeled by the growth of new capillaries from preexisting...
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Molecular imaging is a key component of 21st-century cancer management. The vascular endothelial growth factor (VEGF)/VEGF receptor signaling pathway and integrin alpha v beta 3, a cell adhesion molecule, play pivotal roles in regulating tumor angiogenesis, the growth of new blood vessels. This review summarizes the current status of tumor angiogenesis imaging with SPECT, PET, molecular MRI, ta...
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ژورنال
عنوان ژورنال: Genes & Cancer
سال: 2011
ISSN: 1947-6019,1947-6027
DOI: 10.1177/1947601911432334